Multi-scale simulations to assess chromatin organization along the nuclear periphery

Chromatin's complex and heterogeneous structure along the nuclear periphery plays a crucial role in regulating gene expression and function. As peripheral chromatin aggregates in lamin-associated domains (LADs), diverse interactions with lamina proteins, interior chromatin, and other LADs make modeling difficult. Here, we develop a multi-scale model leveraging the natural organization of chromosomes into territories to navigate chromatin's glassy energetic landscape. This work provides accurate chromatin maps showing different types of LADs, highlighting chromosome conformation and positioning as important factors in LAD strength.