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Genome Organization and Subnuclear Phenomena I: From DNA-Protein Interactions to Higher-Order Structures

FOCUS · Q06 · ID: 1067904

Presentations

  • Light, CRISPR and DNA repair

    ORAL · Invited

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    Publication: R. S. Zou, A. Marin-Gonzalez, Y. Liu, H. B. Liu, L. Shen, R. Dveirin, J.X.J. Luo, R. Kalhor and T. Ha, "Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites" Nature Cell Biology 24, 1433-Y. Liu, R. S. Zou, S. He, Y. Nihongaki, X. Li, S. Razavi, B. Wu and T. Ha, "Very fast CRISPR on demand", Science 368, 1265–1269 (2020).

    Presenters

    • Taekjip Ha

      Johns Hopkins University

    Authors

    • Taekjip Ha

      Johns Hopkins University

    View abstract →

  • A polymer model to infer 3D chromosome structures from Hi-C

    ORAL

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    Publication: L. Liu, M. H. Kim, C. Hyeon, Biophys. J. (2019) 117, 613-625<br>L. Liu, C. Hyeon, Nucl. Acids Res. (2020) 48, 11486-11494<br>L. Liu, B. Zhang, C. Hyeon, PLoS Comp. Biol. (2021) 17, e1009669<br>L. Liu, X. Cao, B. Zhang, C. Hyeon, Biophys. J. (2022) https://doi.org/10.1016/j.bpj.2022.09.018

    Presenters

    • Changbong Hyeon

      Korea Inst for Advanced Study, Korea Institute for Advanced Study

    Authors

    • Changbong Hyeon

      Korea Inst for Advanced Study, Korea Institute for Advanced Study

    • Lei Liu

      Zhejiang Sci-Tech University

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  • Extended and dynamic linker histone-DNA interactions control chromatosome compaction

    ORAL

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    Publication: - S. Rudnizky, H. Khamis, Y. Ginosar, E. Goren, P. Melamed and A. Kaplan, "Extended and dynamic linker histone-DNA interactions control chromatosome compaction", Molecular Cell 81, 3410 (2021)<br><br>- B. Bar-Sadeh, S. Rudnizky, L. Pnueli, G. R. Bentley, R. Stöger, A. Kaplan and P. Melamed, "Unravelling the role of epigenetics in reproductive adaptations to early-life environment", Nature Reviews Endocrinology (2020)<br><br>- S. Rudnizky*, H. Khamis*, O. Malik, P. Melamed, and A. Kaplan, "The base pair-scale diffusion of nucleosomes modulates binding of transcription factors", PNAS 116, 12161 (2019).

    Presenters

    • Ariel Kaplan

      Technion - Israel Institute of Technology

    Authors

    • Ariel Kaplan

      Technion - Israel Institute of Technology

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  • Higher-order genetic interactions in sequence-function relationships

    ORAL

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    Publication: Juannan Zhou, Mandy S. Wong, Wei-Chia Chen, Adrian R. Krainer, Justin B. Kinney and David M. McCandlish, 2022. Higher-order epistasis and phenotypic prediction, PNAS, 119(39).<br>Wei-Chia Chen, Juannan Zhou, Jason M Sheltzer, Justin B. Kinney, and David M. McCandlish, 2020. Field-theoretic density estimation for biological sequence space with applications to 5' splice site diversity and aneuploidy in cancer, PNAS, 118(40). <br>Juannan Zhou and David M. McCandlish, 2020. Minimum epistasis interpolation for sequence-function relationships, Nature Communications, 11(1), pp.1-14.

    Presenters

    • Juannan Zhou

      University of Florida

    Authors

    • Juannan Zhou

      University of Florida

    View abstract →