Analyzing Dynamical Differences Between Vaccinated and Unvaccinated RSV Patients

Respiratory Syncytial Virus (RSV) is a common respiratory virus that can cause serious illness in infants and the elderly. Vaccines for RSV have recently been introduced and have been shown to reduce the severity of the disease, although there has been limited examination of how viral dynamics differ between vaccinated and unvaccinated individuals. Here, we use data from the MVA-BN-RSV Phase II vaccine study to quantify the differences in dynamics between those who have been vaccinated versus those who were unvaccinated. We use an ordinary differential equation model to fit the data, finding that vaccinated patients experience a higher variance in response as compared to the placebo group. This result could have implications for the use of MVA-BN-RSV in vaccination.