Exploring Biological Systems: The Transformative Power of SIngle Molecule and Single Cell Spectroscopy

Single molecule and single cell force spectroscopy of biomolecules, biomaterials, and live cells have provided valuable quantitative information on the thermodynamics and mechanics of these systems. In these studies, biomolecules or cells are pulled, and their responses monitored. Using atomic force microscope (AFM), we explored systems from molecules to cells to understand their equilibrium and dynamic properties. This force signature analysis serves as a tool for investigating various biomedical issues, including multimeric proteins and cancer cells. I will be presenting our force spectroscopy studies, covering topics from protein and DNA mechanics to graphene nanoribbons' biopolymer behavior and cancer physics.