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NMR Spectroscopic Investigation of the Effect of Lithium on Neuroblastoma Metabolism

ORAL

Abstract

Neuroblastoma is a cancer typically found in the adrenal glands that impacts early nerve cells with a majority of cases occurring in children and infants. Previous work has shown that lithium has been utilized with other neurological ailments to block phosphofructokinase pathways in glycolysis. This work seeks to investigate the impact that lithium has upon the metabolic pathways of neuroblastoma, specifically in regard to lithium's influence on lactate production via glycolysis and pentose phosphate pathway. Preliminary results on the metabolic effects of lithium on [U-$^{\mathrm{13}}$C]D-glucose will be discussed along with other supporting data. This study is supported by the Welch Foundation grant AT-1877, DOD grants W81XWH-21-1-0176 and W81XWH-19-1-0741, CPRIT grant RP180716, and the UTD CoBRA and SPIRE grants.

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Authors

  • Cody Larsen

    University of Texas at Dallas

  • Chao Ma

    University of Texas at Arlington, Florida International University, Texas A&M University-Commerce, Texas A&M University–Commerce, University of Houston Downtown, Texas A\&M University, Carnegie Mellon University, Department of Physics, MSEC, Texas State University, Ingram School of Engineering, MSEC, Texas State University, MSEC, Texas State University, Ingram School of Engineering, Texas State University, Department of Chemistry and Biochemistry, North Carolina Central University, Durham, NC 27707, USA, Department of Electrical Engineering, The Pennsylvania State University, University Park, PA 16802, USA, Texas Tech University, Texas A&M University, University of San Francisco, University of Wuppertal, University of Illinois at Urbana-Champaign, University of Houston, University of Texas at Dallas, Mitchell Institute for Fundamental Physics and Astronomy, Texas A & M University, Center for Neutrino Physics, Department of Physics Virginia Tech, None, Department of Physics, University of Texas at Dallas, Department of Electrical Engineering, Yale University

  • Chao Ma

    University of Texas at Arlington, Florida International University, Texas A&M University-Commerce, Texas A&M University–Commerce, University of Houston Downtown, Texas A\&M University, Carnegie Mellon University, Department of Physics, MSEC, Texas State University, Ingram School of Engineering, MSEC, Texas State University, MSEC, Texas State University, Ingram School of Engineering, Texas State University, Department of Chemistry and Biochemistry, North Carolina Central University, Durham, NC 27707, USA, Department of Electrical Engineering, The Pennsylvania State University, University Park, PA 16802, USA, Texas Tech University, Texas A&M University, University of San Francisco, University of Wuppertal, University of Illinois at Urbana-Champaign, University of Houston, University of Texas at Dallas, Mitchell Institute for Fundamental Physics and Astronomy, Texas A & M University, Center for Neutrino Physics, Department of Physics Virginia Tech, None, Department of Physics, University of Texas at Dallas, Department of Electrical Engineering, Yale University