Assessing the Bioactivity of Biotite for Radical Scavenging to Reduce Oxidative Stress via Physicochemical and Quantum Chemical Analysis

Biotite is a naturally occurring phyllosilicate mineral that shows great potential as an inorganic therapeutic agent. Due to its unique structure and chemicophysical properties, obtained data imply that it reduces oxidative toxicity that leads to cancer and neurodegenerative diseases. The substance demonstrates its therapeutic value through characteristics that enable it to neutralize harmful reactive oxygen species (ROS). Biotite achieves its optimal electronic structure through its built-in iron (Fe²⁺/Fe³⁺) redox couple, which makes it an effective ROS quencher. The low band gap of biotite enables it to transfer electrons efficiently because this process is essential for stopping free radicals. The high reactivity of biotite becomes measurable through its low chemical hardness and high electrophilicity values, which show its strong ability to accept unstable radical electrons. The strong surface binding energy of biotite enables it to effectively capture ROS molecules, which it then neutralizes through its structure. The mineral shows a strong ability to donate electrons, which enables direct radical detoxification.

Our computational modeling and data analysis employing analytical chemistry show that biotite stands apart from muscovite and talc because it has a low band gap, which makes it reactive, while these other phyllosilicates remain inert. The electronic properties of chlorite match those of biotite, but the latter outperforms through its strong radical adsorption capabilities and its highly reactive electron-donating surface. The mineral maintains both high reactivity and strong structural stability because of its large dipole moment and favorable thermodynamic properties, which makes it suitable for biological applications.

Presented molecular analysis shows the biotite stands out as an excellent therapeutic candidate because it combines beneficial properties, including a suitable band gap and high cation exchange capacity and strong binding energy and strong redox activity. The substance demonstrates strong radical adsorption capabilities and stability, which makes it an effective agent for treating cellular redox imbalances and oxidative stress-related tissue damage.