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Detection of novel cardiovascular disease factor using electrochemical impedance spectroscopy with gold nano-thin-film electrodes

ORAL

Abstract

Cardiovascular disease (CVD) is a leading cause of death worldwide. Angiotensin-converting enzyme 2 (ACE2) is a novel plasma biomarker for CVD. Traditional methods for ACE2 detection, such as quenching fluorescent substrates (QFS) are expensive, time-consuming, and high background. In this study, we have developed a gold nano-thin-film electrode by plasma sputtering technique for electrochemical impedance spectroscopy (EIS). By using Au-NTF-EIS detection system, the ACE2 concentration can be detected from 0.65 fM to 6.5 pM, within 2 mins. Based on its advantages the risk factors of CVDs can be revealed.

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Presenters

  • Cheng-Wei Du

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan, ROC

Authors

  • Cheng-Wei Du

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan, ROC

  • Chia-Yu Chang

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan, ROC, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, National Yang Ming Chiao Tung University

  • Hao-Syun Chou

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan, ROC, Department of Biological Science and Technology, National Yang Ming Chiao Tung University

  • Yu-Chun Lin

    National Yang Ming Chiao Tung University

  • Yu-Chaun Liang

    Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan

  • Chia-Ching Chang

    National Yang Ming Chiao Tung University, Department of Biological Science and Technology, National Yang Ming Chiao Tung University