Bioinspired Phase Separation

FOCUS · MAR-W64 · ID: 3095171

Presentations

  • Synthetic biomolecular condensates from the co-transcriptional folding and assembly of de-novo designed RNA nanostructures

    ORAL · Invited

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    Publication: [1] Fabrini, G. et al. Co-transcriptional production of programmable RNA condensates and synthetic organelles.
    Nature Nanotechnology, https://doi.org/10.1038/s41565-024-01726-x, (2024).
    [2] Paraschiv, A.-A. et al. Nonequilibrium morphologies in multiphase RNA condensates, in preparation
    [3] Farag, N. et al. Modulating enzymatic reactions with genetically encoded RNA condensates, in preparation
    [4] Ng, B.*, Dordevic, M* et al. Expression of membrane-less organelles in E. coli from de-novo designed RNA building blocks, in preparation

    Presenters

    • Lorenzo Di Michele

      Cambridge University

    Authors

    • Lorenzo Di Michele

      Cambridge University

    View abstract →

  • DNA Liquid Droplets Embedded in Cytoskeletal Networks

    ORAL

    –

    Presenters

    • Samuel Wilken

      University of California, Santa Barbara, UC Santa Barbara

    Authors

    • Samuel Wilken

      University of California, Santa Barbara, UC Santa Barbara

    • Kyu Hwan Choi

      University of California, Santa Barbara

    • Austin Hopkins

      University of California, Santa Barbara

    • M. Cristina Marchetti

      University of California, Santa Barbara

    • Zvonimir Dogic

      University of California, Santa Barbara

    • Sho C Takatori

      University of California, Santa Barbara

    • Omar A. Saleh

      University of California, Santa Barbara

    View abstract →

  • Unraveling the Entropic Influence of Crowded Environments on the Structure of Coacervate Droplets

    ORAL

    –

    Presenters

    • Atanu Baksi

      University of Notre Dame

    Authors

    • Atanu Baksi

      University of Notre Dame

    • Jonathan K Whitmer

      University of Notre Dame

    • Mohsen Farshad

      University of Notre Dame

    • Arthur Odenheimer

      University of California, Los Angeles

    • Riddhi Kaley

      University of California, Los Angeles

    • Samanvaya Srivastava

      University of California, Los Angeles, UCLA, UCLA Department of Chemical and Biomolecular Engineering

    • Isabel Knight

      University of Notre Dame

    • Nga Nguyen

      University of Notre Dame

    View abstract →

  • Depletion of monovalent cations limits the coexistence regime of the DNA nanostar liquid-liquid phase diagram

    ORAL

    –

    Publication: Planned publication: "Depletion of monovalent cations limits the coexistence regime of the DNA nanostar liquid-liquid phase diagram"

    Presenters

    • Thomas J Reese

      University of California, Santa Barbara

    Authors

    • Thomas J Reese

      University of California, Santa Barbara

    • Nicholas M Phelps

      University of California Santa Barbara

    • David C Ewart

      University of California, Santa Barbara

    • Deborah K Fygenson

      University of California, Santa Barbara

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  • Interplay between Basepairing and Electrostatic Interactions Determines the Phase Behaviors of DNA Nanostar and Polylysine Mixtures

    ORAL

    –

    Publication: We are preparing a manuscript for this work. The paper should be available by the time of presentation.

    Presenters

    • Tianhao Li

      Princeton University

    Authors

    • Tianhao Li

      Princeton University

    • Gabrielle R Abraham

      University of California, Santa Barbara, University of Southern California

    • Omar A. Saleh

      University of California, Santa Barbara

    • William M Jacobs

      Princeton University

    View abstract →

  • Polyelectrolyte coacervates as model protocells for stable RNA compartmentalization

    ORAL

    –

    Publication: 1. A. Agrawal, J. F. Douglas, M. V. Tirrell, A. Karim, Manipulation of coacervate droplets with an electric field. Proc. Natl. Acad. Sci. U.S.A. 119, e2203483119 (2022).
    2. A. Baksi, H. Zerze, A. Agrawal, A. Karim, G. H. Zerze, The molecular picture of the local environment in a stable model coacervate, Communications Chemistry, 7, 1 (2024).
    3. A. Agrawal, A. Radakovic, A. Vonteddu, S. Rizvi, V. H. Huynh, J. F. Douglas, M. V. Tirrell, A. Karim, J. W. Szostak, Did the exposure of coacervate droplets to rain make them the first stable protocells?, Science Advances 10, eadn9657 (2024).

    Presenters

    • Aman Agrawal

      University Of Chicago

    Authors

    • Aman Agrawal

      University Of Chicago

    • Alamgir Karim

      University Of Houston, University of Houston

    • Matthew V Tirrell

      University of Chicago

    • Jack W Szostak

      University of Chicago

    View abstract →

  • Phase Separation on Deformable Membranes: interplay of mechanical coupling and dynamic surface geometry

    ORAL

    –

    Publication: Winter, Antonia, et al. "Phase Separation on Deformable Membranes: interplay of mechanical coupling and dynamic surface geometry." arXiv preprint arXiv:2409.16049 (2024)

    Presenters

    • Antonia Winter

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    Authors

    • Antonia Winter

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    • Yuhao Liu

      Ludwigs-Maximilian-Universitaet (LMU Munich)

    • Alexander Ziepke

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    • George Dadunashvili

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    • Erwin A Frey

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    View abstract →