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Bioinspired Phase Separation

FOCUS · MAR-W64 · ID: 3095171

Presentations

  • Synthetic biomolecular condensates from the co-transcriptional folding and assembly of de-novo designed RNA nanostructures

    ORAL · Invited

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    Publication: [1] Fabrini, G. et al. Co-transcriptional production of programmable RNA condensates and synthetic organelles.<br>Nature Nanotechnology, https://doi.org/10.1038/s41565-024-01726-x, (2024).<br>[2] Paraschiv, A.-A. et al. Nonequilibrium morphologies in multiphase RNA condensates, in preparation<br>[3] Farag, N. et al. Modulating enzymatic reactions with genetically encoded RNA condensates, in preparation<br>[4] Ng, B.*, Dordevic, M* et al. Expression of membrane-less organelles in E. coli from de-novo designed RNA building blocks, in preparation<br>

    Presenters

    • Lorenzo Di Michele

      Cambridge University

    Authors

    • Lorenzo Di Michele

      Cambridge University

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  • DNA Liquid Droplets Embedded in Cytoskeletal Networks

    ORAL

    –

    Presenters

    • Samuel Wilken

      University of California, Santa Barbara, UC Santa Barbara

    Authors

    • Samuel Wilken

      University of California, Santa Barbara, UC Santa Barbara

    • Kyu Hwan Choi

      University of California, Santa Barbara

    • Austin Hopkins

      University of California, Santa Barbara

    • M. Cristina Marchetti

      University of California, Santa Barbara

    • Zvonimir Dogic

      University of California, Santa Barbara

    • Sho C Takatori

      University of California, Santa Barbara

    • Omar A. Saleh

      University of California, Santa Barbara

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  • Unraveling the Entropic Influence of Crowded Environments on the Structure of Coacervate Droplets

    ORAL

    –

    Presenters

    • Atanu Baksi

      University of Notre Dame

    Authors

    • Atanu Baksi

      University of Notre Dame

    • Jonathan K Whitmer

      University of Notre Dame

    • Mohsen Farshad

      University of Notre Dame

    • Arthur Odenheimer

      University of California, Los Angeles

    • Riddhi Kaley

      University of California, Los Angeles

    • Samanvaya Srivastava

      University of California, Los Angeles, UCLA, UCLA Department of Chemical and Biomolecular Engineering

    • Isabel Knight

      University of Notre Dame

    • Nga Nguyen

      University of Notre Dame

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  • Depletion of monovalent cations limits the coexistence regime of the DNA nanostar liquid-liquid phase diagram

    ORAL

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    Publication: Planned publication: "Depletion of monovalent cations limits the coexistence regime of the DNA nanostar liquid-liquid phase diagram"

    Presenters

    • Thomas J Reese

      University of California, Santa Barbara

    Authors

    • Thomas J Reese

      University of California, Santa Barbara

    • Nicholas M Phelps

      University of California Santa Barbara

    • David C Ewart

      University of California, Santa Barbara

    • Deborah K Fygenson

      University of California, Santa Barbara

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  • Interplay between Basepairing and Electrostatic Interactions Determines the Phase Behaviors of DNA Nanostar and Polylysine Mixtures

    ORAL

    –

    Publication: We are preparing a manuscript for this work. The paper should be available by the time of presentation.

    Presenters

    • Tianhao Li

      Princeton University

    Authors

    • Tianhao Li

      Princeton University

    • Gabrielle R Abraham

      University of California, Santa Barbara, University of Southern California

    • Omar A. Saleh

      University of California, Santa Barbara

    • William M Jacobs

      Princeton University

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  • Polyelectrolyte coacervates as model protocells for stable RNA compartmentalization

    ORAL

    –

    Publication: 1. A. Agrawal, J. F. Douglas, M. V. Tirrell, A. Karim, Manipulation of coacervate droplets with an electric field. Proc. Natl. Acad. Sci. U.S.A. 119, e2203483119 (2022).<br>2. A. Baksi, H. Zerze, A. Agrawal, A. Karim, G. H. Zerze, The molecular picture of the local environment in a stable model coacervate, Communications Chemistry, 7, 1 (2024).<br>3. A. Agrawal, A. Radakovic, A. Vonteddu, S. Rizvi, V. H. Huynh, J. F. Douglas, M. V. Tirrell, A. Karim, J. W. Szostak, Did the exposure of coacervate droplets to rain make them the first stable protocells?, Science Advances 10, eadn9657 (2024).

    Presenters

    • Aman Agrawal

      University Of Chicago

    Authors

    • Aman Agrawal

      University Of Chicago

    • Alamgir Karim

      University Of Houston, University of Houston

    • Matthew V Tirrell

      University of Chicago

    • Jack W Szostak

      University of Chicago

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  • Phase Separation on Deformable Membranes: interplay of mechanical coupling and dynamic surface geometry

    ORAL

    –

    Publication: Winter, Antonia, et al. "Phase Separation on Deformable Membranes: interplay of mechanical coupling and dynamic surface geometry." arXiv preprint arXiv:2409.16049 (2024)

    Presenters

    • Antonia Winter

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    Authors

    • Antonia Winter

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    • Yuhao Liu

      Ludwigs-Maximilian-Universitaet (LMU Munich)

    • Alexander Ziepke

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    • George Dadunashvili

      Ludwig-Maximilians-Universitaet (LMU-Munich)

    • Erwin A Frey

      Ludwig-Maximilians-Universitaet (LMU-Munich)

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  • Theory for sequence selection via phase separation and oligomerization

    ORAL

    –

    Publication: https://arxiv.org/abs/2410.08778

    Presenters

    • Ivar S Haugerud

      University of Augsburg

    Authors

    • Ivar S Haugerud

      University of Augsburg

    • Giacomo Bartolucci

      Max Planck Institute for the Physics of Complex Systems

    • Dieter Braun

      Ludwig Maximilian University

    • Christoph A Weber

      University of Augsburg

    View abstract →