Genetic networks underying EMT are minimally frustrated
ORAL · Invited
Abstract
Biological networks that control cell fate decisions, such as the one governing the epithelial-mesenchymal transition (EMT), seem incomprehensibly complex, involving both many factors and many different levels of regulatory interactions (transcriptional, translational, epigenetic, metabolic, ...). Yet, the number of truly distinct states seen in many biological processes seems relatively small and manageable. Here, we will discuss how ideas of minimally frustrated networks and low dimensional dominance can help us make sense of this paradox. We will also discuss how these ideas can also help us understand how different aspects of cellular physiology may become usefully correlated.
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Publication: Tripathi, S., Kessler, D.A. and Levine, H., 2023. Minimal frustration underlies the usefulness of incomplete regulatory network models in biology. Proceedings of the National Academy of Sciences, 120(1), p.e2216109120.<br><br>Tripathi, S., Kessler, D.A. and Levine, H., 2020. Biological networks regulating cell fate choice are minimally frustrated. Physical Review Letters, 125(8), p.088101.<br><br>Jia, D., Park, J.H., Kaur, H., Jung, K.H., Yang, S., Tripathi, S., Galbraith, M., Deng, Y., Jolly, M.K., Kaipparettu, B.A. and Onuchic, J.N., 2021. Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer. British Journal of Cancer, 124(12), pp.1902-1911
Presenters
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Herbert Levine
Northeastern University, Northeastern Univ
Authors
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Herbert Levine
Northeastern University, Northeastern Univ