Intracellular transport in the presence of dynamical microtubule organizing center.
POSTER
Abstract
In our recent work Biophysical Reports 4(3), 100171 (2024), we calculated statistical properties of intracellular cargo transport in the presence of convergent microtubule morphologies with absorbing boundary conditions at the cell membrane. This was done for static conditions in the context of a one-dimensional model. However, the cytoskeleton is often dynamic. For example, cytotoxic T lymphocytes undergo a dynamic reorganization of the microtubule organizing center (MTOC), along with the rest of the microtubule apparatus during an immune response. In this poster I will present the extension of our one-dimensional model to the case of a moving MTOC. I will discuss what is considered a slow-enough motion for which the phenomenon can be said to be in the adiabatic regime, and the calculate rates at which cargo escapes under these conditions. We compare our numerical predictions with explicit simulations of cargo in one dimensional microtubule filament geometries with a moving MTOC.
Presenters
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Oleg Kogan
Queens College, City University of New York, Department of Physics, Queens College, City University of New York
Authors
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Oleg Kogan
Queens College, City University of New York, Department of Physics, Queens College, City University of New York
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Ankush G Kumar
University of California, Merced, Department of Physics, University of California Merced
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Ajay Gopinathan
University of California, Merced, Dept. of Physics, UC Merced, Department of Physics, University of California, Merced