Oral: Pattern Formation Controls Mitotic Scaling through Dynamic Phosphoinositide Signalling

Self-organizing pattern formation are present in numerous biological systems. Our recent work in mitotic mast cells show that formation of periodic travelling waves can be scale invariant, where the period of its temporal pattern is proportional to the size of the mitotic cells. Identifying mechanisms that can achieve scale invariant pattern formation is important for characterizing the spatial information they contain and its impact on scaling.



Here we present experimental evidences that self-organizing travelling waves on the cortex is modulated by membrane-dependent signaling networks. We show that these patterns are tunable by altering phosphoinositide signaling network and intracellular trafficking. Our results highlight the vital role of a dynamical systems view in understanding size sensing, positioning of mitotic structures and singularity of cell division.