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The CAPGLO Device: magnetic fields and magnetic particles, disease capture with fluorescent imaging

ORAL

Abstract

The CAPGLO project is an ongoing research and development aimed at creating a low-cost solution to address a need for an easily accessible and portable disease component capture and detection device. Our past success in such solutions for disease diagnostics has earned us two US Patent Office "Patent for Humanity) awards for malaria detection. This invention was subsequently successfully commercialized. The project has gone on to utilize magnetic beads and fluorescent dye to mark cells of interest. These cells are concentrated via a magnetic gradient force and imaged using fluorescent microscopy. With past success in Lyme, virus, and cancer applications, we have now expanded the CAPGLO device to focus on cancer t-cells. We will report on the experiments to capture and concentrate t-cells with the aim of developing effective immunotherapy.

Publication: From an obliquely falling rod in a viscous fluid to the motion of suspended magnetic bead chains that are driven by a gradient magnetic field and that make an arbitrary angle with the magnetic force vector: A Stokes flow study; PLOS ONE - Published: April 16, 2024<br>https://doi.org/10.1371/journal.pone.0301852

Presenters

  • Robert W Brown

    Case Western Reserve University

Authors

  • Robert W Brown

    Case Western Reserve University

  • Robert J Deissler

    CWRU

  • Patrick M Deluca

    CWRU