Hemodynamic correlates of cardiovascular intrinsic frequencies: a model-based study

It is well accepted that arterial pressure waveforms provide information about cardiac dynamics, arterial function, and the coupling between the two. Various clinical (Cooper, et al., Hypertension 2021, PMID: 33390053) and pre-clinical (Alavi, et al., J Am Heart Assoc. 2024, PMID: 39258553) studies have demonstrated the significance of the intrinsic frequency (IF) method for the analysis of cardiovascular systems and the diagnostics of cardiovascular diseases. However, the hemodynamic determinants of cardiovascular IFs have not been fully established in a controlled study where one determinant (e.g., LV contractility) is changing while other determinants (e.g., arterial stiffness, total compliance) are kept constant. In this work, a well-established and validated 1D blood flow and pulse wave propagation model of the entire circulatory system is employed in order to investigate the hemodynamic correlates of IFs with respect to various cardiac functions and vasculature effects. Such studies are essential for understanding the mechanisms of various cardiovascular diseases and their relationship to IF parameters (clinically significant since IFs can be determined via non-invasive, uncalibrated pressure measurements including those obtained by a smartphone camera or wearable device).