Physics of the Immune System II
FOCUS · MAR-G72 · ID: 3112002
Presentations
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Epistatic hotspots boost antibody evolvability
ORAL
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Presenters
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Shenshen Wang
University of California, Los Angeles
Authors
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Shenshen Wang
University of California, Los Angeles
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Steven Schulz
University of California, Los Angeles
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Timothy Tan
University of Illinois at Urbana-Champaign
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Nicholas C Wu
University of Illinois at Urbana-Champaign
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Specificity, sensitivity, and energy dissipation in kinetic proofreading: a mechanistic revisit
ORAL
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Publication: Li, X., & Chou, T. (2024). Reliable ligand discrimination in stochastic multistep kinetic proofreading: First passage time vs. product counting strategies. PLOS Computational Biology, 20(6), e1012183.
Presenters
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Xiangting Li
University of California, Los Angeles
Authors
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Xiangting Li
University of California, Los Angeles
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Tom Chou
University of California, Los Angeles
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Mechanisms of expansion of small clones: Insights from multispecies stochastically driven models
ORAL
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Presenters
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Yunbei Pan
UCLA
Authors
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Yunbei Pan
UCLA
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Tom Chou
University of California, Los Angeles
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Stochasticity and epigenetic heritability of B-cell fate decisions are necessary for efficient affinity maturation of the antibody repertoire
ORAL
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Presenters
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Haripriya Vaidehi Narayanan
University of California, Los Angeles
Authors
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Mark Y Xiang
University of Califronia, Los Angeles, University of California, Los Angeles
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Haripriya Vaidehi Narayanan
University of California, Los Angeles
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Alexander Hoffmann
UCLA, University of California, Los Angeles
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Exploring B Cell Dynamics and Immunological Feedback in Vaccination: A Computational Approach to Affinity Maturation
ORAL
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Presenters
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Saeed Mahdisoltani
Massachusetts Institute of Technology
Authors
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Saeed Mahdisoltani
Massachusetts Institute of Technology
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Mehran Kardar
Massachusetts Institute of Technology
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Arup K Chakraborty
Massachusetts Institute of Technology
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Mechanism for evolution of antibodies in response to HIV broadly neutralizing antibody therapy
ORAL
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Publication: D. Kannan, E. Wang, S. Lewin, S. Deeks, A. K. Chakraborty. "Mechanism for evolution of potent autologous antibodies upon broadly neutralizing antibody therapy of people with HIV" (In Preparation)
Presenters
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Deepti Kannan
Massachusetts Institute of Technology
Authors
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Deepti Kannan
Massachusetts Institute of Technology
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Eric Wang
Massachusetts Institute of Technology
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Sharon Lewin
University of Melbourne
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Steven Deeks
University of California, San Francisco
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Arup K Chakraborty
Massachusetts Institute of Technology
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Adaptive mechanical proofreading: a pathway to enhanced humoral immunity
ORAL
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Presenters
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Qing Xu
Stanford University
Authors
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Qing Xu
Stanford University
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Shenshen Wang
University of California, Los Angeles
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Active mechanical patterning of the immune synapse
ORAL
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Presenters
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Suraj Shankar
University of Michigan
Authors
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Suraj Shankar
University of Michigan
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Tony Wong
University of California, Los Angeles
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Tom Chou
University of California, Los Angeles
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Shenshen Wang
University of California, Los Angeles
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Using mathematical modelling to estimate the efficacy of BCG vaccination on Mycobacterium tuberculosis dynamics and dissemination in ultra-low dose infected mice
ORAL
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Presenters
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Dipanjan Chakraborty
Texas Biomedical Research Institute
Authors
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Dipanjan Chakraborty
Texas Biomedical Research Institute
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Vitaly V Ganusov
Texas Biomedical Research Institute
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Of friends and foes - how to educate the immune system
ORAL · Invited
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Publication: Banerjee A, Pattinson DJ, Wincek CL, Bunk P, Chapin SR, Navlakha S*, Meyer HV* (2024) BATMAN: Improved T cell receptor cross-reactivity prediction benchmarked on a comprehensive mutational scan database, bioRxiv 2024.01.22.576714 (under review)<br><br>Kovaleva VA, Pattinson DJ, Barton C, Chapin SR, Minervina AA, Richards KA, Sant AJ, Thomas PG*, Pogorelyy MV*, Meyer HV* (2023) copepodTCR: Identification of Antigen-Specific T Cell Receptors with combinatorial peptide pooling, bioRxiv 2023.11.28.569052
Presenters
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Hannah Meyer
Cold Spring Harbor Laboratory
Authors
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Hannah Meyer
Cold Spring Harbor Laboratory
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Biophysical Modeling for Predicting Human T Cell Repertoire Specificity
ORAL
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Publication: Wang A, Lin X, Chau KN, Onuchic JN, Levine H, George JT. RACER-m leverages structural features for sparse T cell specificity prediction. Science Advances. 2024;10(20):eadl0161.
Presenters
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Jason T George
Texas A&M University College Station
Authors
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Jason T George
Texas A&M University College Station
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Topological measures on phylogenetic trees of the antibody repertoire reveal the underlying kinetics of B-cell fate decisions
ORAL
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Presenters
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Chengyuan Li
University of California, Los Angeles
Authors
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Chengyuan Li
University of California, Los Angeles
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Jianche Liu
Zhejiang University
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Mark Y Xiang
University of Califronia, Los Angeles, University of California, Los Angeles
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Helen Huang
University of California, Los Angeles
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Haripriya Vaidehi Narayanan
University of California, Los Angeles
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Alexander Hoffmann
UCLA, University of California, Los Angeles
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Modeling the mechanisms for formation of LAT condensates
ORAL
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Presenters
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Yannick Azhri Din Omar
Massachusetts Institute of Technology
Authors
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Yannick Azhri Din Omar
Massachusetts Institute of Technology
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L.J. Nugent Lew
University of California, Berkeley
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Saehyun Choi
University of California, Berkeley
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Jay T Groves
University of California, Berkeley
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Mehran Kardar
Massachusetts Institute of Technology
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Arup K Chakraborty
Massachusetts Institute of Technology
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