Stabilization of Complex Coacervate Emulsions by Comb Polyelectrolytes: Effects of Comb Polyelectrolyte Attributes

Complex coacervates are commonly found in nature, are vital for many cell processes, and may potentially provide insights into the origin of life scenarios. Synthetic complex coacervates have been used for various purposes, including as enzymatic reactors and stabilizers. Once stabilized, these emulsions can be used for numerous other applications, such as drug carriers or for use in cosmetics. We have previously demonstrated robust stabilization of complex coacervate microdroplets by comb polyelectrolytes. In this presentation, the synthesis and characterization of a library of comb polyelectrolytes (cPEs) with diverse backbone and sidechain lengths, as well as varied sidechain densities, will be discussed. By utilizing this cPE library, an assessment of the critical chain characteristics that govern emulsion stability will be presented. We will also discuss how these different architectures interplay with the necessary concentrations to achieve robust stabilization. By relying on our findings, we will put forward guidelines for designing macromolecules that localize and stabilize at the coacervate-water interface.



This research was supported by the National Science Foundation under grant no. DMR-2048285.