DNA-Associated Biomolecular Condensates

Presentations

• The interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening

  ORAL · Invited

  March 18, 2025, 11:00 AM – March 18, 2025, 11:36 AM

  Publication: D.S. Banerjee+, T. Chigumira+, R.M. Lackner, J.C. Kratz, D.M. Chenoweth, S. Banerjee*, H. Zhang*. Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening. bioRxiv: https://doi.org/10.1101/2024.05.07.593010.

  Presenters

  • Huaiying Zhang

    Carnegie Mellon University

  Authors

  • Huaiying Zhang

    Carnegie Mellon University

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• Physical mechanisms underlying spatial targeting of chromatin-associated biomolecular condensates

  ORAL

  March 18, 2025, 11:36 AM – March 18, 2025, 11:48 AM

  Publication: [1] Strom, Amy R., Jorine M. Eeftens, Yury Polyachenko, Claire J. Weaver, Hans-Frederick Watanabe, Dan Bracha, Natalia D. Orlovsky, Chanelle C. Jumper, William M. Jacobs, and Clifford P. Brangwynne. "Interplay of condensation and chromatin binding underlies BRD4 targeting." Molecular biology of the cell 35, no. 6 (2024): ar88.; https://doi.org/10.1091/mbc.E24-01-0046

  Presenters

  • Yury Anatolievich Polyachenko

    Princeton University

  Authors

  • Yury Anatolievich Polyachenko

    Princeton University

  • Hans-Frederick Watanabe

    Princeton University

  • Alexey Korolev

    Princeton University

  • William M Jacobs

    Princeton University

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• Active RNA synthesis patterns nuclear condensates

  ORAL

  March 18, 2025, 11:48 AM – March 18, 2025, 12:00 PM

  Publication: Active RNA synthesis patterns nuclear condensates. Salman F. Banani, Andriy Goychuk, Pradeep Natarajan, Ming M. Zheng, Giuseppe Dall'Agnese, Jonathan E. Henninger, Mehran Kardar, Richard A. Young, Arup K. Chakraborty. bioRxiv 2024.10.12.614958; doi: https://doi.org/10.1101/2024.10.12.614958

  Presenters

  • Andriy Goychuk

    Massachusetts Institute of Technology

  Authors

  • Andriy Goychuk

    Massachusetts Institute of Technology

  • Pradeep Natarajan

    Massachusetts Institute of Technology

  • Salman F Banani

    University of Chicago

  • Ming M Zheng

    Whitehead Institute

  • Giuseppe Dall'Agnese

    Whitehead Institute

  • Jonathan E Henninger

    Carnegie Mellon University

  • Mehran Kardar

    Massachusetts Institute of Technology

  • Richard A Young

    Whitehead Institute

  • Arup K Chakraborty

    Massachusetts Institute of Technology

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• Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates

  ORAL

  March 18, 2025, 12:00 PM – March 18, 2025, 12:12 PM

  Publication: Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates
  Lingyu Meng, Sheng Mao, Jie Lin
  Proceedings of the National Academy of Sciences (PNAS), 121 (12), e2316610121, 2024

  Presenters

  • Jie Lin

    Peking University

  Authors

  • Jie Lin

    Peking University

  • Lingyu Meng

    Peking University

  • Sheng Mao

    Peking University

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• Computational Studies of Liquid-Liquid Phase Separation within Elastic and Inelastic Networks

  ORAL

  March 18, 2025, 12:12 PM – March 18, 2025, 12:24 PM

  Presenters

  • Ji Qi

    Princeton University

  Authors

  • Ji Qi

    Princeton University

  • Mikko P Haataja

    Princeton University

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• Brownian Dynamics Simulation of Dps:DNA Condensate Formation in Starved E. Coli

  ORAL

  March 18, 2025, 12:24 PM – March 18, 2025, 12:36 PM

  Presenters

  • Alberto Alonso

    Rochester Institute of Technology

  Authors

  • Alberto Alonso

    Rochester Institute of Technology

  • Lauren Melcher

    Rochester Institute of Technology

  • Elio A Abbondanzieri

    University of Rochester

  • Anne S Meyer

    University of Rochester

  • Moumita Das

    Rochester Institute of Technology

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• Histone tail-DNA condensates show acetylation-dependent viscoelastic coupling to single DNA mechanics

  ORAL

  March 18, 2025, 12:36 PM – March 18, 2025, 12:48 PM

  Presenters

  • Priya R Banerjee

    The State University of New York at Buffalo

  Authors

  • Priya R Banerjee

    The State University of New York at Buffalo

  • Davit Potoyan

    Iowa State University

  • Emma Morrison

    Medical College of Wisconsin

  • Ritika Gupta

    The State University of New York at Buffalo

  • Anurag Singh

    The State University of New York at Buffalo

  • Erin Hammonds

    Medical College of Wisconsin

  • Joseph Basalla

    The State University of New York at Buffalo

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• A thermodynamic study of condensate formation in a mixture of DNA-binding protein from starved cells (Dps) and DNA

  ORAL

  March 18, 2025, 12:48 PM – March 18, 2025, 1:00 PM

  Presenters

  • Soumik Mitra

    Rochester Institute of Technology

  Authors

  • Soumik Mitra

    Rochester Institute of Technology

  • Luke Studt

    Rochester Institute of Technology

  • Elio A Abbondanzieri

    University of Rochester

  • Anne S Meyer

    University of Rochester

  • Moumita Das

    Rochester Institute of Technology

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• Elastocapillary interaction between condensate and chromatin

  ORAL

  March 18, 2025, 1:00 PM – March 18, 2025, 1:12 PM

  Presenters

  • Hongbo Zhao

    Princeton University, University of California San Diego, University of California, San Diego

  Authors

  • Hongbo Zhao

    Princeton University, University of California San Diego, University of California, San Diego

  • Amy Strom

    Princeton University

  • Mikko P Haataja

    Princeton University

  • Andrej Kosmrlj

    Princeton University

  • Cliff Brangwynne

    Princeton University

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• Single molecule studies of chromatin structure in transcription condensates

  ORAL

  March 18, 2025, 1:12 PM – March 18, 2025, 1:24 PM

  Presenters

  • Jan Spille

    University of Illinois Chicago

  Authors

  • Jan Spille

    University of Illinois Chicago

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• Measuring Chromatin-nucleolus Interactions in Living Cells

  ORAL

  March 18, 2025, 1:24 PM – March 18, 2025, 1:36 PM

  Presenters

  • Yu-Chieh Chung

    The Ohio State University

  Authors

  • Yu-Chieh Chung

    The Ohio State University

  • Li-Chun Tu

    The Ohio State University

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• Cluster size determines morphology of transcription factories in human cells

  ORAL

  March 18, 2025, 1:36 PM – March 18, 2025, 1:48 PM

  Presenters

  • Giuseppe Negro

    University of Edinburgh

  Authors

  • Giuseppe Negro

    University of Edinburgh

  • Davide Marenduzzo

    University of Edinburgh

  • Massimiliano Semeraro

    University of Bari

  • Giada Forte

    University of Edinburgh

  • Giuseppe Gonnella

    University of Bari

  • Antonio Suma

    Università degli studi di Bari

  • Peter R Cook

    University of Oxford

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• Limits to concentration sensing in inhomogeneous environments

  ORAL

  March 18, 2025, 1:48 PM – March 18, 2025, 2:00 PM

  Presenters

  • Nicholas Lawson

    Princeton University

  Authors

  • Nicholas Lawson

    Princeton University

  • William S Bialek

    Princeton University

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