Effects of dissipative junctional adhesion on confluent tissue viscoelasticity and dynamics

Cell migration is crucial in various physiological processes, such as embryonic development, wound healing, and cancer metastasis. Cell-cell adhesion has been shown to play a significant role in tissue dynamics by influencing the cell shape. However, the dissipative aspect of cell-cell adhesion has not been thoroughly studied. In this work, we investigate the impact of dissipative cell-cell adhesion on tissue dynamics and collective cell migration using a dissipative junctional vertex model. We highlight the competition between the tensional and dissipative aspects of cell-cell adhesion. While increasing tensional adhesion promotes cell migration by altering cell shape, increasing viscous adhesion can lead to jamming of the system. Furthermore, we demonstrate a direct relationship between viscous cell-cell adhesion and collective migration, confirming the key role of cell-cell adhesion in maintaining the coherence of tissue dynamics.