STRUCTURE AND DIFFUSION OF LYSOZYME IN IONIC SOLUTION

Lysozyme is an antimicrobial enzyme that is fundamental to the innate immune response. Like all proteins, lysozyme's function is dependent upon folding into its native state. By introducing the protein into solutions with varying ion concentrations, we can visualize the effect these conditions have on the stability of the protein. Using GROMACS molecular dynamics simulator. We study how different concentrations of sodium chloride influence proper folding of lysozyme. Once this state of equilibrium was reached, various structural properties of the protein were measured including the radius of gyration, mean square displacement and the radial distribution function. Our goal is to find what conditions increase the stability and what is the dynamics of ions on the enzyme.