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Interactions of APOA and EMI

POSTER

Abstract

The APOA proteins role in lipid metabolism is crucial, as it contributes to the high-density lipoprotein (HDL) particles that circulate in the blood to transport fat from tissues to the liver. The conformation of the APOA protein is important in its functioning within the HDL particles. Interactions with solutes or molecules can influence the hydrogen bonding of the protein, which can alter its conformational structure and tertiary shape. These interactions can potentially increase stability but also potentially denature the protein. Our goal is to study this protein and understand how it interacts with the EMI ions. We will determine the interactions of the APOA protein with different concentrations of the ions and water by running molecular dynamic simulations using GROMACS. We hope to understand if the ion can potentially stabilize the APOA protein, making it more effective in the body.

Authors

  • Madelyn Thompson

    The University of Tennessee at Chattanooga

  • Robert Grzywacz

    Moscow Institute of Physics and Technology, University of Virginia, California Institute of Technology, National High Magnetic Field Laboratory, University and Student Affairs; Oak Ridge Laboratory, Brookhaven National Laboratory, Physicist, Brookhaven National Laboratory, Oak Ridge National Laboratory, USA, Center for Nuclear Study, University of Tokyo, Advanced Science Research Center, Japan Atomic Energy Agency, Florida State University, Presidency University, Kolkata, INDIA, VECC,Kolkata, INDIA, SINP,Kolkata, INDIA, UGC-DAE CSR (Kolkata), INDIA, IFIN-HH, ELI-NP, Romania, Variable Energy Cyclotron Centre,Kolkata, INDIA, IEM, Kolkata, India, Victoria Institution (College), Kolkata, INDIA, Variable Energy Cyclotron Centre, Kolkata, INDIA, NHMFL; Florida State University, FAMU-FSU College of Engineering, Florida State University, Physics Department, Florida State University, Mississippi State University, NHMFL-FSU, U. Colorado at Boulder, NHMFL, University of Alabama at Birmingham, Oak Ridge National Laboratory, Argonne National Laboratory, Alabama School of Math and Science, University of South Alabama, University of Florida, University of Notre Dame, University of Texas at Dallas, Bob Jones University, University of Tennessee at Chattanooga, The Autonomous University of San Luis Potosí, Northern Arizona University, Flagstaff, AZ, Harvard-Smithsonian Center for Astrophysics, Cambridge, National Institute of Standards and Technology, Clemson University, University of South Florida, Phenikaa University, University of Ulsan, Ohio University, University of Hawaii, University of California, Davis, University of California, Davis., Saleh Research Centre, Department of Physics, Florida State university, Tallahassee, FL32306, USA, WestCHEM, School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK, Professor, facility manager, Student, Florida State University(Former), Hebrew University, Israel \& Ioffe Institute, St.\ Petersburg, Russia, University of Tennessee, Knoxville

  • Luis Sanchez-Diaz

    University of Tennessee at Chattanooga, The University of Tennessee at Chattanooga