Back to basics: a lattice framework for understanding coil-globule transitions in polymers

Coil-to-globule transitions in polymers have been observed in a wide range of systems and can be induced in a variety of ways (e.g., exposure to heat, addition of cosolvent). However, the precise physics and chemistries that determine whether coil-globule transitions occur is not fully understood, and to date, there is no universal theoretical or computational framework that can generically describe the transformation subject to multiple forms of stimuli. In this talk, I will describe a simple, lattice framework that allows us to capture and elucidate the physics of coil-globule transition induced either by heat or cononsolvency. By thorough investigation of numerous interaction types and energetic regimes, we provide a general roadmap that supports a broader understanding of stimuli-response in polymeric systems.