Two Dimensional Imaging Using a Single-Sided Field Free Line Magnetic Particle Scanner
ORAL
Abstract
Magnetic Particle Imaging (MPI) is a promising tracer-based preclinical biomedical imaging modality, which could be used for detection and treatment of cancer. The images created in MPI consist solely of hot spots of a tracer without background, which is similar to images from PET and SPECT. In MPI superparamagnetic iron oxide nanoparticles (SPIONs) are excited by an AC magnetic field and the signal detected by a receive coil. For spatial encoding a gradient magnetic field is applied, which creates a field free region (FFR). At the location of the FFR the SPIOs are maximally sensitive to the excitation, moving the FFR allows sampling the local concentration of SPIOs in region of interest. A major challenge currently in MPI is scaling up a scanner to a human size making MPI clinically useful. Construction of a full body closed bore scanner has been shown impractical due to high power consumption. An alternative solution is the single-sided scanner's geometry providing an unrestricted access to the imaging volume. Our group is developing a single-sided scanner, which uses a field free line as an FFR promising higher sensitivity and more robust image reconstruction techniques. In this work we demonstrate the first 2D imaging of various phantoms as a proof of principle of our design.
–
Publication: [1] Pagan, J., McDonough, C., Vo, T. and Tonyushkin, A. 2021. Single-sided magnetic particle imaging device with field-free-line geometry for in vivo imaging applications. IEEE Transactions on Magnetics 57(2), p. 5300105<br><br>[2] Chinchilla, C., McDonough, C., Negash, A., Pagan, J. and Tonyushkin, A. 2021. Simulation studies of image reconstruction for field free line single-sided magnetic particle imaging scanner. International journal on magnetic particle imaging 7(1), p. 2104001.<br><br>[3] McDonough, C., Newey, D. and Tonyushkin, A. 2022. 1-d imaging of a superparamagnetic iron oxide nanoparticle distribution by a single-sided ffl magnetic particle imaging scanner. IEEE Transactions on Magnetics 58(8), p. 6501105.
