Structural and Dynamic signatures of active chromatin polymers

Maintenance of the chromatin structure is an active process since many ATP-consuming proteins are simultaneously applying forces at microscopic lengthscales. We model activity in coarse-grained chromatin as an additive persistent noise and explore the role of active forces in shaping the structure and dynamics of chromatin. We propose activity as an important force regulating genome structural characteristics, such as chromosome compaction and nuclear positioning. Importantly, this model predicts novel structural and dynamic regimes, and key experimentally testable signatures associated with activity, that otherwise may not be captured in an effective-equilibrium model.