Fe@Ag-Matrix Magnetic Nanoparticles for Hyperthermia Cancer Therapy

Magnetic nanoparticles have garnered much attention due to their diverse usage in biomedicine such as MRI, drug delivery, and cancer therapy. Although iron oxide nanoparticles are often chosen, bimetallic nanoparticles have become an innovative approach to use in biomedicine. We have synthesized an Iron-Silver magnetic nanoparticle matrix using Iron-Sulfate and Sodium Citrate with Sodium Borohydride as a reducing agent. The time of injection of Silver Nitrate to the ferrous salt solution will give us different sized particles and different magnetic saturations. Using VSM we measured a magnetic saturation of 226 emu/g for an injection time of seven minutes. We tested the viability of the magnetic nanoparticles in hyperthermia therapy by inducing an alternating magnetic field to test their heating capabilities. The magnetic saturation values give an idea as to how dispersive the particles will be during the hyperthermia therapy. We have also functionalized the Iron-Silver magnetic nanoparticles using plant-based coating to add a layer of protection to the particles and increase their dispersive properties when used during treatment. We have also used the characterization techniques of XRD and SEM to analyze the crystal structure and size of the particles.