Relating quantitative ultrasound measurements of two cancer cell lines, HeLa and MDA-MB-231, to biological markers

Cancer is the second most common cause of death in the United States; 1.9 million new cases are expected to be diagnosed in 2022. Measurement of ultrasonic tissue properties can be an important diagnostic tool for distinguishing between malignant and benign tumors, and may possibly be used for detection of cancer. Speed of sound and attenuation as a function of frequency between 2 and 18 MHz were measured and compared for Hela and MDA cell lines using a narrowband substitution technique. The results of these measurements are compared to bio-markers in the cells to identify posible mechamisims for differences in their ultrasonic properties.