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Brain Organoids: From morphogenesis to metamaterials

INVITED · A13 · ID: 783455

Presentations

  • Linear viscoelastic properties of the vertex model for biological tissues

    ORAL · Invited

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    Publication: * S. Tong, R. Sknepnek, and A. Kosmrlj, "Linear viscoelastic response of the vertex model with internal and external dissipation: normal modes analysis", arXiv:2202.03261 (2022)<br>* S. Tong, N. K. Singh, R. Sknepnek, and A. Kosmrlj, "Linear viscoelastic properties of the vertex model for epithelial tissues", PLoS Computational Biology 18, e1010135 (2022)

    Presenters

    • Andrej Kosmrlj

      Princeton, Princeton University

    Authors

    • Andrej Kosmrlj

      Princeton, Princeton University

    • Sijie Tong

      Princeton University

    • Rastko Sknepnek

      University of Dundee

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  • Brain organoids: New models to study neural development and disease

    ORAL · Invited

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    Publication: 1. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubeita L, Taxidis J, Khakh B, Coppola G, Pearson C, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, and Novitch BG. Self-organized cerebral organoids with human specific features predict effective drugs to combat Zika virus infection. 2017. Cell Reports, 21(2):517-532<br><br>2. Li C, Deng YQ, Wang S, Ma F, Aliyari R, Huang XY, Zhang NN, Watanabe M, Dong HL, Liu P, Li ZF, Ye Z, Tian M, Hong, S, Fan J, Zhao H, Li L, Vishlaghi N, Au C, Liu Y, Lu N, Du P, Qin FXF, Zhang B, Novitch BG, Xu Z, Qin CF, and Cheng G. 25-Hydroxycholesterol protects host against ZIKV infection and its associated mirocephaly. 2017. Immunity, 46(3):1-11.<br><br>3. Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, and Novitch BG. Identification of neural oscillations and epileptic changes in human brain organoids. 2021. Nat Neurosci, 24(10):1488-1500.<br><br>4. Watanabe M, Haney J, Vishlaghi N, Turcios F, Buth JE, Gu W, Collier AJ, Miranda OA, Chen D, <br>Clark A, Plath K, Gandal M, and Novitch BG. TGF? superfamily signaling regulates the state of human pluripotency and competency to create telencephalic organoids. 2022. Stem Cell Reports, 17(10):2220-2238.

    Presenters

    • Momoko Watanabe

      University of California, Irvine

    Authors

    • Momoko Watanabe

      University of California, Irvine

    • Jessie E Buth

      University of California, Los Angeles

    • Neda Vishlaghi

      University of California, Los Angeles

    • Felix Turcios

      University of California, Los Angeles

    • Ranmal A Samarasinghe

      University of California, Los Angeles

    • Bennett G Novitch

      University of California, Los Angeles

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  • Brain Folds and the Extracellular Matrix: Lessons from Brain Organoids

    ORAL · Invited

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    Publication: Maayan Karlinski, Irit Sagi, Amnon Buxboim, Orly Reiner (in preparation). ECM changes and Mechanical Properties of LIS1-/+ Brain Organoids.<br><br>Aditya Kshirsagar, Anna Gorelik, Tsviya Olender, Tamar Sapir, Daisuke Tsuboi, Irit Rosenhek-Goldian, Sergey Malitsky, Maxim Itkin, Amir Argoetti, Yael Mandel-Gutfreund, Sidney R. Cohen, Jacob Hanna, Igor Ulitsky, Kozo Kaibuchi, Orly Reiner. LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways. bioRxiv 2022.03.08.483407; doi: https://doi.org/10.1101/2022.03.08.483407<br><br>Karzbrun E, Kshirsagar A, Cohen SR, Hanna JH, Reiner O. Human Brain Organoids on a Chip Reveal the Physics of Folding. Nat Phys. 2018 May;14(5):515-522. doi: 10.1038/s41567-018-0046-7. Epub 2018 Feb 19. PubMed PMID: 29760764; PubMed Central PMCID: PMC5947782

    Presenters

    • Orly Reiner

      Weizmann Institute of Science

    Authors

    • Orly Reiner

      Weizmann Institute of Science

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  • Towards building brains using in vitro biology across scales

    ORAL · Invited

    –

    Presenters

    • J. M Schwarz

      Syracuse University, Department of Physics and BioInspired Institute, Syracuse University, Syracuse, NY 13244, USA

    Authors

    • J. M Schwarz

      Syracuse University, Department of Physics and BioInspired Institute, Syracuse University, Syracuse, NY 13244, USA

    View abstract →