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Biomolecular Phase Separation I - Interactions, Thermodynamics and Mechanics

FOCUS · S06 · ID: 46258

Presentations

  • A Molecular View of Liquid-Liquid Phase Separation of Disordered Proteins

    ORAL · Invited

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    Publication: 1. Zheng W*,Dignon GL*, Xu X, Regy RM, Best RB, Zheng W, Mittal J, "Molecular details of protein condensates probed by microsecond-long atomistic simulations",Journal of Physical Chemistry B,124, 11671-11679.<br>2. Schuster BS*,Dignon GL*, Jahnke CN, Simpkins AG, Hammer DA, Good MC, Mittal J, "Identifying Sequence Perturbations to an Intrinsically Disordered Protein that Determine its Phase Separation Behavior",Proceedings of the National Academy of Sciences,117, 11421-11431.<br>3. Zheng W, Dignon GL, Brown M, Kim YC, Mittal J, "Hydropathy patterning complements charge patterning to describe conformational preferences of disordered proteins",Journal of Physical Chemistry Letters,11, 3408-415.<br>4. Dignon GL*, Zheng W*, Kim YC, Mittal J, "Temperature controlled liquid-liquid phase separation of disordered proteins",ACS Central Science,5, 821-830.<br>5. Dignon GL*, Zheng W*, Best RB, Kim YC, Mittal J, "Relation between single-molecule properties and phase behavior of intrinsically disordered proteins",Proceedings of theNational Academy of Sciences,115, 9929-9934.<br>6. Dignon GL*, Zheng W*, Kim YC, Best RB, Mittal J, "Sequence determinants of protein phase behavior from a coarse-grained model",PLOS Computational Biology,14,e1005941.

    Presenters

    • Gregory Dignon

      Stony Brook University (SUNY)

    Authors

    • Gregory Dignon

      Stony Brook University (SUNY)

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  • Phase separation vs aggregation behavior for model disordered proteins

    ORAL

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    Publication: Ushnish Rana, Clifford P. Brangwynne, and Athanassios Z. Panagiotopoulos , "Phase separation vs aggregation behavior for model disordered proteins", J. Chem. Phys. 155, 125101 (2021) https://doi.org/10.1063/5.0060046

    Presenters

    • Ushnish Rana

      Princeton University

    Authors

    • Ushnish Rana

      Princeton University

    • Cliff Brangwynne

      Princeton University

    • Athanassios Panagiotopoulos

      Princeton University

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  • Nucleation in multicomponent liquid mixtures

    ORAL

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    Presenters

    • Andrej Kosmrlj

      Princeton University, Princeton

    Authors

    • Josep Bataller i Umbert

      Polytechnic University of Catalonia

    • Mikko Haataja

      Princeton University

    • Sheng Mao

      Peking University

    • Andrej Kosmrlj

      Princeton University, Princeton

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  • On the interplay between phase separation and aggregation

    ORAL

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    Publication: On the interplay between phase separation and aggregation [in prep.]

    Presenters

    • Giacomo Bartolucci

      Max Planck Institute for the Physics of Complex Systems

    Authors

    • Giacomo Bartolucci

      Max Planck Institute for the Physics of Complex Systems

    • Thomas C Michaels

      Harvard University

    • Christoph A Weber

      University of Augsburg, Institute of Physics, Institute of Physics, University of Augsburg, Institute of Physics University of Augsburg

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  • Computational design of amino-acid sequence variations that modulate the liquid-liquid phase separation of intrinsically disordered proteins

    ORAL

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    Publication: - Joseph, Reinhardt et al., Physics driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy, Nat.Comput. Sci., 2021 (in press).<br>- Lichtinger et al, Targeted modulation of protein liquid–liquid phase separation by evolution of amino-acid sequence, Plos Comp Biol, 2021

    Presenters

    • Maria J Maristany

      Univ of Cambridge

    Authors

    • Maria J Maristany

      Univ of Cambridge

    • Jerelle A Joseph

      University of Cambridge

    • Rosana Collepardo-Guevara

      University of Cambridge

    • Aleks Reinhardt

      University of Cambridge

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