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Physics of Genome Organization: Phase Separation

FOCUS · Q06 · ID: 46218

Presentations

  • Chromatin constrains the formation, diffusion, and coarsening of phase-separated condensates

    ORAL · Invited

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    Publication: Lee, D.S.W., Wingreen, N.S. & Brangwynne, C.P. Chromatin mechanics dictates subdiffusion and coarsening dynamics of embedded condensates. Nat. Phys. 17, 531–538 https://doi.org/10.1038/s41567-020-01125-8 Jan 11 (2021)<br><br>Zhang Y, Lee DSW, Meir Y, Brangwynne CP, Wingreen NS. Mechanical frustration of phase separation In the cell nucleus by chromatin. Phys Rev Lett. Jun 25;126(25):258102. Doi: 10.1103/Physrevlett.126.258102. PMID: 34241518. (2021)

    Presenters

    • Ned S Wingreen

      Princeton University

    Authors

    • Ned S Wingreen

      Princeton University

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  • The polymer model of constitutive heterochromatin

    ORAL

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    Publication: Currently, we are working on two manuscripts which will be posted to biorxiv soon. One focuses on the theoretical and analytical aspects of the model, while the other looks at its application to the organization of constitutive heterochromatin.

    Presenters

    • Ramin Basir

      University of Pennsylvania

    Authors

    • Ramin Basir

      University of Pennsylvania

    • Vivek b Shenoy

      University of Pennsylvania

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  • Mesoscale modeling of the dynamics of phase-separated chromatin compartments in eukaryotic nucleus

    ORAL

    –

    Publication: [1] A liquid state perspective on dynamics of chromatin compartments, R. Laghmach, M. Di Pierro and D. A. Potoyan, Submitted to Frontiers Biophysics<br>[2] The interplay of chromatin phase separation and lamina interactions in nuclear organization, R. Laghmach, M. Di Pierro and D. A. Potoyan, Biophysical Journal (2021) https://doi.org/10.1016/j.bpj.2021.10.012<br>[3] Mesoscale liquid model of chromatin recapitulates nuclear order of eukaryotes, R. Laghmach, M. Di Pierro and D. A. Potoyan, Biophysical Journal, 0006-3495 (2020) https://doi.org/10.1016/j.bpj.2019.09.013

    Presenters

    • Rabia Laghmach

      Iowa State University

    Authors

    • Rabia Laghmach

      Iowa State University

    • Michele Di Pierro

      Northeastern University

    • Davit Potoyan

      Iowa State University

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  • Resolving chromatin landscapes around nuclear condensates

    ORAL

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    Presenters

    • Jan-Hendrik Spille

      University of Illinois at Chicago

    Authors

    • Jan-Hendrik Spille

      University of Illinois at Chicago

    • Ganesh Pandey

      Department of Physics, University of Illinois at Chicago

    • Aishwarya Katiki

      Department of Physics, University of Illinois at Chicago

    • Saurabh Priyadarshi

      Department of Microbiology and Immunology, University of Illinois at Chicago

    • Filmon Medhanie

      Department of Physics, University of Illinois at Chicago

    • Amy L Kenter

      Department of Microbiology and Immunology, University of Illinois at Chicago

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  • Single molecule tracking reveals distinct mobility states that contribute to the dynamics and function of nuclear receptors

    ORAL

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    Presenters

    • Kaustubh Wagh

      University of Maryland, College Park/Laboratory of Receptor Biology and Gene Expression, NIH

    Authors

    • Kaustubh Wagh

      University of Maryland, College Park/Laboratory of Receptor Biology and Gene Expression, NIH

    • Rikke AM Jensen

      Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense

    • R. Louis Schiltz

      Laboratory of Receptor Biology and Gene Expression, NCI, NIH

    • Ville Paakinaho

      Institute of Biomedicine, University of Eastern Finland, Kuopio

    • Susanne Mandrup

      Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense

    • Diego M Presman

      Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET-Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires

    • Arpita Upadhyaya

      University of Maryland, College Park

    • Gordon L Hager

      Laboratory of Receptor Biology and Gene Expression, NIH

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  • Nonlinear mechanics of human mitotic chromosomes

    ORAL

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    Presenters

    • Janni Harju

      Vrije Universiteit Amsterdam

    Authors

    • Janni Harju

      Vrije Universiteit Amsterdam

    • Anna Meijering

      Vrije Universiteit Amsterdam

    • Kata Sarlós

      University of Copenhagen

    • Christian F Nielsen

      University of Copenhagen

    • Hannes Witt

      Vrije Universiteit Amsterdam

    • Emma Kerklingh

      Vrije Universiteit Amsterdam

    • Guus H Haasnoot

      Vrije Universiteit Amsterdam

    • Anna H Bizard

      University of Copenhagen

    • Iddo Heller

      Vrije Universiteit Amsterdam

    • Ying Liu

      University of Copenhagen

    • Erwin Peterman

      Vrije Universiteit Amsterdam

    • Ian D Jackson

      University of Copenhagen

    • Gijs Wuite

      Vrije Universiteit Amsterdam

    • Chase P Broedersz

      Department of Physics and Astronomy, Vrije Universiteit Amsterdam, Netherlands & Arnold-Sommerfeld-Center for Theoretical Physics and Center for NanoScience, LMU, Germany, Vrije Universiteit Amsterdam

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  • Enzymatic activity in chromatin organization

    ORAL

    –

    Presenters

    • Rakesh Das

      Mechanobiology Institute, National University of Singapore, Singapore 117411

    Authors

    • Rakesh Das

      Mechanobiology Institute, National University of Singapore, Singapore 117411

    • Takahiro Sakaue

      Department of Physical Sciences, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, JAPAN

    • G. V. Shivashankar

      Paul Scherrer Institute, Villigen, Switzerland

    • Jacques Prost

      Laboratoire de Physique Statistique, Laboratoire Physico Chimie Curie, Institut Curie, Paris Sciences Lettres Research University, CNRS UMR168, 75005 Paris, France

    • Tetsuya Hiraiwa

      Mechanobiology Institute, National University of Singapore, Singapore 117411

    View abstract →