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Delbruck Prize Symposium

INVITED · N14 · ID: 42186

Presentations

  • Delbruck Prize (2022): Resource Allocation for Bacteria Growth: Laws and Mechanisms

    ORAL · Invited

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    Publication: [1] M. Scott, C. W. Gunderson, E. Mateescu, Z. Zhang, T. Hwa. "Inter-dependence of Cell Growth and Gene Expression: Origins and Consequences". Science 330: 1099-1102 (2010).<br>[2] C. You, H. Okano, S. Hui, Z. Zhang, M. Kim, C.W. Gunderson, Y.P. Wang, P. Lenz, D. Yan, T. Hwa, "Coordination of bacterial proteome with metabolism by cAMP signaling", Nature 500: 301-6 (2013). <br>[3] S. Hui, J.M. Silverman, S.S. Chen, D.W. Erickson, M. Basan, J. Wang, T. Hwa, J.R. Williamson. "Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria", Mol. Syst. Biol. 11: 786-799 (2015).<br>[4] M. Mori, Z. Zhang, A. Banaei-Esfahani, J.B. Lalanne, H. Okano, B.C. Colins, A. Schmidt, O.T. Schubert, D.S. Lee, G.W. Li, R. Aebversold, T. Hwa, C. Ludwig. "From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions". Mol. Syst. Biol. 17: e9536 (2021).<br>[5] D.W. Erickson, S. Schink, V. Patsalo, J. R. Williamson, U. Gerland, T. Hwa. "A global resource allocation strategy governs growth transition kinetics of E. coli", Nature 551: 119-123 (2017). <br>[6] M. Basan, S. Hui, Z. Zhang, Y. Shen, J.R. Williamson, T. Hwa. "Overflow metabolism in E. coli results from efficient proteome allocation", Nature 528: 99-104 (2015).<br>[7] J.B. Deris, M. Kim, Z. Zhang, H. Okano, R. Hermsen, A. Groisman, T. Hwa. "The innate growth bistability of antibiotic resistant bacteria". Science 342: 1237435 (2013).<br>[8] M. Basan, T. Honda, D. Christodoulou, M. Hoerl, H. Okano, B.R. Taylor, J.M. Silverman, J.R. Williamson, T. Hwa, U. Sauer. "A universal tradeoff between growth and lag in fluctuating environments." Nature 584: 470-474 (2020).<br>[9] C. Wu, Z. Zhang, A. Banaei-Esfahani, H. Okano, M. Mori, R. Aebersold, C. Ludwig, T. Hwa. "Proteome reserves define the onset of enzyme recovery across biosynthesis pathways." (in preparation).<br>[10] 139. T. Hwa. "Cell behavior and control" in The Physics of Living Matter: Space, Time, and Information in Biology, Proceeding of the 27th Solvay Conference on Physics. D.J. Gross, A. Sevrin, B. Shraiman, Eds. (World Scientific, 2020).<br>[11] C. Wu, R. Balakrishnan, M. Mori, G. Manzanarez, Z. Zhang, T. Hwa. "Cellular perception of growth rate and the mechanistic origin of bacterial growth laws." bioRxiv 2021.10.16.464649.

    Presenters

    • Terence T Hwa

      University of California, San Diego, UCSD

    Authors

    • Terence T Hwa

      University of California, San Diego, UCSD

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  • Esther Hoffman Beller Lectureship (2022): Growth-rate dependent action of cell-wall targeting antibiotics

    ORAL · Invited

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    Presenters

    • Rosalind J Allen

      Friedrich-Schiller Universität Jena

    Authors

    • Rosalind J Allen

      Friedrich-Schiller Universität Jena

    • Rebecca Brouwers

      University of Edinburgh

    • Sharareh Tavaddod

      University of Edinburgh

    • Leonardo Mancini

      University of Cambridge

    • Elizabeth Tatham

      University of Edinburgh

    • Pietro Cicuta

      University of Cambridge

    • Waldemar Vollmer

      University of Newcastle

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  • TBA

    ORAL · Invited

    –

    Presenters

    • Boris I Shraiman

      University of California, Santa Barbara

    Authors

    • Boris I Shraiman

      University of California, Santa Barbara

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