Non-ideality in lipid mixtures, a molecular dynamics study

Biological membranes are complex environments characterized by multicomponent lipid mixtures[1]. We investigate in this work binary lipid bilayers using the SPICA coarse-grained molecular dynamics model.  Adapting the Kirkwood-Buff theory of liquid mixtures [2] to finite wavelegth density fluctuations statistics, we compare various practical approaches for determining the interaction parameters in a theory of regular solution description of these numerical lipid mixtures.

[1] Ole G. Mouritsen, L. A. Bagatolli. Life - As A Matter Of Fat  Springer-Verlag GmbH, 2015

[2] A. Ben-Naim, Water and Aqueous Solutions: Introduction to a Molecular Theory Plenum Press, 1974