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Anti-SARS-Cov-2 infection drugs and neutralizing antibody screening by palladium nano-thin-film electrode-based biosensor

POSTER

Abstract

Outbreak of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has infected more than 240 million people and caused nearly five million death. In order to alleviate the symptoms of viral infections and severe illness, drugs/functional peptides to suppressed the virus infection are highly desired. A rapid and sensitive anti-viral infection drugs screening sensing system has been developed by mimicking the SARS-CoV-2 enters the cell model. Four potential leads have been identified, such as perindoprilat and ramiprilat, which can reduce virus infection 67% and 72%, respectively by palladium nano-thin-film electrode-based biosensor (Pd-NTF biosensor) within 21 mins and at low analyte concentration and small volume (0.1 μg/mL and ~1 μL, estimated total analyte consumption < 4 pg). Furthermore, the titer of neutralizing antibody can be analyzed and the effective titer is as high as 19500.

Publication: 1. Kiew L.V., et al., (2021) Biosencers&Bioelectronics 183,11321<br>2. Chang C.-Y., et al., (2019) Appl. Phys. Lett.114,093702<br>

Presenters

  • Yi-Xuan Huang

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Authors

  • Yi-Xuan Huang

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

  • Lik-Voon Kiew

    Department of pharmacology,Faculty of Medicine,University of Malaya, 50603 Kuala Lumpur,Malaysia

  • Chia-Hsing Cheng

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan

  • Chia-Yu Chang

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan

  • Yen chen Chen

    Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

  • Chia-Ching Chang

    Department of Biological Science and Technology, Natl Chiao Tung Univ, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan