A new evolutionary perspective on drug(g)ability

Drug(g)ability is a classical concept in pharmacology that describes properties of drug targets in some cases, and of small molecules in others. In this seminar, I unpack this ambiguity, and introduce new metrics that quantify the likelihood that (i) a given drug is effective across alleles, and that (ii) alleles are treatable by a panel of drugs. Further, we resolve drug-variant interactions into very specific higher-order terms between mutations that construct alleles and drug environments. We interpret these results in light of modern questions in evolutionary biomedicine and in the context of the growing science of higher-order complex biological systems.