Actin-microtubule networks as time-varying rigidly percolating double networks
ORAL
Abstract
The cytoskeleton is a dynamic composite scaffold made of networks of different types of biopolymers, primarily actin filaments and microtubules, and motor proteins. Here we present results from Langevin Dynamics simulations of a model that combines two structure-function frameworks: a double network (DN) made of a network of stiff filaments (microtubules) interacting with a network of flexible filaments (actin), and rigidity percolation theory. We present results for the collective time-evolving mechanical response of these composites with and without active elements (myosin and kinesin motors), and obtain a phase diagram in the space of concentrations of actin, microtubules, and motors. Our results can provide mechanistic insights into the contractility and restructuring of active cytoskeletal composites and the rational design of materials inspired by them.
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Presenters
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Moumita Das
Rochester Institute of Technology
Authors
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Moumita Das
Rochester Institute of Technology
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Pancy Lwin
Rochester Institute of Technology
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Jonathan A Michel
Georgia Institute of Technology
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Lauren Melcher
Rochester Institute of Technology
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Michael J Rust
University of Chicago, Department of Molecular Genetics and Cell Biology, University of Chicago
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Jennifer L Ross
Syracuse University, Department of Physics, Syracuse University
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Rae M Anderson
University of San Diego, Department of Physics and Biophysics, University of San Diego, 5998 Alcala Park, San Diego, CA, 92110, USA, University San Diego, Department of Physics and Biophysics, University of San Diego