Chromatin Structure and Activity Modifies Dynamics and Interactions

The static structure of geni loci can now be investigated by 3C experiments [1] and computer simulations [2]. Yet, the loci dynamics is far less understood and much more difficult to investigate experimentally.
In this talk I will discuss the HiP-HoP model to predict the mobility of the Pax6 locus in mouse cell lines with different expression states. Interestingly, we observe that the locus dynamics is strongly correlated to the transcriptional activity, post-translational modifications and the formation of cohesin mediated loops.
These simulations are the first step to understand the relationship between loci mobility and their expression.

[1] Dekker, Job, et al. "Capturing chromosome conformation." science 295.5558 (2002): 1306-1311.
[2] Buckle, Adam, et al. "Polymer simulations of heteromorphic chromatin predict the 3D folding of complex genomic loci." Molecular cell 72.4 (2018): 786-797.