Entropy Driven Assemblies in Dilute Solution

There have been numerous studies using well-defined blends to recapitulate hierarchical assemblies using DNA, peptide, protein, block copolymer, supramolecule as well as colloids. The work can be divided into two camps to the first approximation, those using precise intra- and inter-molecular interactions and those using entropy-driven phase behavior. However, the exact origin of system diversity and complexity, which are abundant in natural system such as cell wall, cytosol, and any given body fluids, remains mysterious. I will describe a recent studies showing that chemical diversity and complexity can enhance system miscibility such that entropy-driven phase behavior can be realized in composites.