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Photoswithchable upconverting nanoparticles

ORAL

Abstract

Photoswitchable fluorescent markers including flurorescent proteins, organic fluorophores, and synthetic photoswitches are workhorses of advanced super-resolution microscopy techniques and has a great potential for a variety of application in optoelectronic logic devices and nanoscale optical memory. Although a plenty of novel photoswitchable molecules or nanoparticles has been developed, photobleaching over multiple cycles, UV light required for activation, or low photostability in water limit the application of these markders, especially in biology. Here, we report photoswitching and blinking behaviors of lanthanide-doped nanocrystal under irradiation in the NIR I and II transparent window which can penetrate deeper in tissue without severe photodamage compared to visible and UV light. We showed this photoswitching of nanocrystals can be repeated over 1000 cycles without significant photobleaching.

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Presenters

  • Changhwan Lee

    Department of Mechanical Engineering, Columbia University, Mechanical Engineering, Columbia University

Authors

  • Changhwan Lee

    Department of Mechanical Engineering, Columbia University, Mechanical Engineering, Columbia University

  • Emma Xu

    Department of Mechanical Engineering, Columbia University

  • Sang Hwan Nam

    Laboratory for Advanced Molecular Probing (LAMP), Korea Research Institute of Chemical Technology

  • Yung Doug Suh

    Laboratory for Advanced Molecular Probing (LAMP), Korea Research Institute of Chemical Technology

  • Bruce Cohen

    The Molecular Foundry, Lawrence Berkeley National Laboratory, Molecular Foundry, Lawrence Berkeley National Laboratory

  • Emory Chan

    The Molecular Foundry, Lawrence Berkeley National Laboratory, Molecular Foundry, Lawrence Berkeley National Laboratory

  • P. James Schuck

    Mechanical Engineering, Columbia University, Columbia University, Department of Mechanical Engineering, Columbia University