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3D Printed Absorber for Capturing Chemotherapy Drugs before they Spread through the Body

ORAL

Abstract

Cancer is becoming the leading cause of death in most developed nations. Despite efforts to develop targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. During intra-arterial chemotherapy infusion to a target organ, typically, more than 50-80% of the injected drug is not trapped in the target organ, bypasses the tumor, and causes severe toxicities in distant locations.

In the context of reducing the toxicity of chemotherapy, we have designed, built, and deployed porous adsorbers for capturing chemotherapy drugs from the blood stream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The porosity was obtained by 3D printing of lattice structures within a cylinder. The surface of porous cylinders was coated with an ion-containing nanostructured block polymer which is responsible for capturing doxorubicin, a widely used chemotherapy drug with significant toxic side effects. Using a swine model, we show that our initial design enables the capture of 69 % of the administered drug without any immediate adverse effects. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.

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Presenters

  • Hee Jeung Oh

    Pennsylvania State University, Chemical Engineering, Pennsylvania State University

Authors

  • Hee Jeung Oh

    Pennsylvania State University, Chemical Engineering, Pennsylvania State University

  • Mariam Aboian

    Radiology and Biomedical Engineering, Yale School of Medicine

  • Michael Yi

    Chemical and Biomolecular Engineering, University of California, Berkeley

  • Jacqueline Maslyn

    Chemical and Biomolecular Engineering, University of California, Berkeley

  • Whitney Loo

    University of California, Berkeley, University of Chicago, Chemical and Biomolecular Engineering, University of California, Berkeley

  • Xi Jiang

    Materials Sciences Division, Lawrence Berkeley National Laboratory, Lawrence Berkeley National Laboratory

  • Dilworth Parkinson

    Advanced Light Source Division, Lawrence Berkeley National Laboratory

  • Mark Wilson

    Department of Radiology, University of California, San Francisco

  • Terilyn Moore

    Department of Radiology, University of California, San Francisco

  • Colin Yee

    Department of Radiology, University of California, San Francisco

  • Gregory Robbins

    Carbon, Inc.

  • Florian Barth

    Carbon, Inc.

  • Joseph DeSimone

    Chemical Engineering, Stanford University

  • Steven Hetts

    Department of Radiology, University of California, San Francisco

  • Nitash Balsara

    University of California, Berkeley, Chemical and Biomolecular Engineering, University of California, Berkeley, College of Chemistry, University of California, Berkeley