Vertex Modelling of Cephalic Furrow Formation

The notion of mechanical cues regulating tissue formation, although, is well known, how the cells orchestrate the information among themselves to generate specific movements is still not fully understood. In the current research, this question has been addressed to discover critical mechanical cues for cephalic furrow formation in Drosophila melanogaster. The 2D Vertex modelling approach has been used to model the relevant segment of the epithelial layer tissue. We have found inverting nature of dynamics in terms of varying stresses along the cellular membrane before and after the invagination occurs. Also the accumulation of increasing stress along the membranes of invaginating cells is another mechanical cue, that we have found critical, to generate the cephalic furrow.