Active folding and coiling in vivo
ORAL
Abstract
A common theme in biology is the assembly of cells into tubes, which in turn develop into specific shapes for specific functions. In a large class of organs including the gut, a simple tube transforms into a coil of compartments. This process is particularly striking in the Drosophila melanogaster midgut -- a tube that folds and then coils into a helical configuration in only two hours. Using a combination of light-sheet microscopy, genetics, and computer vision techniques, we extract the full 3D dynamics of this organ with sub-cellular resolution. We present a quantitative account of the dynamics of folding and coiling of the midgut that links cellular motion and deformation to the macroscopic shape change of the organ.
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Presenters
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Noah Mitchell
KITP, UC Santa Barbara
Authors
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Noah Mitchell
KITP, UC Santa Barbara
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Dillon Cislo
University of California, Santa Barbara
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Suraj Shankar
Harvard, Harvard University, Physics, Harvard University, Physics department, Harvard University
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Zvonimir Dogic
Physics, UC Santa Barbara, University of California Santa Barbara, University of California, Santa Barbara, Physics, University of California Santa Barbara, Physics Department, University of Caifornia Santa Barbara, Physics, University of California, Santa Barbara
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Boris I Shraiman
KITP, UC Santa Barbara, University of California, Santa Barbara
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Sebastian Streichan
University of California, Santa Barbara