<i>In silico</i> studies of “DNA Flossing” through a Double-Nanopore system

We carry out in silico study of “DNA Flossing” (X. Liu et al., bioRxiv: http:/dx.doi.org/10.1101/77817) in a model Double Nanopore Device, where the DNA conformations oscillates back and forth from one nanocavity to the other while translocating through a double nanopore when the linear segment between the nanopores gets scanned. We simulate the conditions for efficient multiple scans as well as the reduction of the variance in measurement of genomic length from these scans. In particular, we vary the dimensions of the cavities, the distance between the nanopores, and nature of the feedback forces to optimize the measurement of genomic lengths through flossing mechanism.