Hydrodynamic effects on the motility of crawling eukaryotic cells

Eukaryotic cell motility is crucial during development, wound healing, the immune response, and cancer metastasis. Some eukaryotic cells can swim, but cells more commonly adhere to and crawl along the extracellular matrix. We study the relationship between hydrodynamics and adhesion that describe whether a cell is swimming, crawling, or combining these motions. Our simple model of a cell, based on the three-sphere swimmer, is capable of both swimming and crawling. As cell-matrix adhesion strength increases, the influence of hydrodynamics on migration diminish. Cells with significant adhesion crawl with speeds much larger than their nonadherent, swimming counterparts. We predict that, while most eukaryotic cells are in the strong-adhesion limit, increasing environment viscosity or decreasing cell-matrix adhesion could lead to hydrodynamic effects even in crawling cells. Signatures of hydrodynamic effects include dependence of cell speed on medium viscosity or the presence of a nearby substrate as well as interactions between noncontacting cells. These signatures are suppressed at large adhesion strengths, but even strongly adherent cells will generate fluid flows advecting passive particles and swimmers.