Self-regulating magnetic hyperthermia (SrMH) of Ni_xCu_1-x nanoparticles

Ni_xCu_1-x (x=0.2-0.5) nanoparticles have been synthesized by reducing Ni and Cu from metal precursors using sol-gel route followed by annealing at different temperatures for controlled self-regulating magnetic hyperthermia applications (SrMH). SEM, TEM, and XRD reveal spherical 20-50 nm nanoparticles with FCC cubic structure for different compositions of Ni_xCu_1-x. The magnetic properties exhibited ferromagnetic behavior with saturation magnetization (M_s) ranging from 8-20 emu/g at 300 K and Curie temperature ranging from 42-25 °C within the limit of the therapeutic temperature range of 42-46 °C. The feasibility of hyperthermia has been performed under the therapeutic limits of alternating magnetic field and frequency. The samples exhibited heating rate and a significant dissipated heating power or measured as specific absorption rate (SAR) ranging from 0.1-1.6 °C/min and 20-100 W/g, respectively. Results reveal nanoparticles' feasibility for self-regulating hyperthermia.