Cyanide Bridged Platinum-Iron Complexes as Cisplatin Prodrug Systems: Design and Computational Study

We present design principles of cyanide bridged Platinum-Iron complexes as novel Platinum(IV) anti-cancer prodrugs that bear the potential of high selectivity towards cancerous cells. The proposed molecular system can release up to six cisplatin anticancer agents per prodrug unit. This functionality of the prodrug is addressed through density functional theory (DFT) calculations that are presented as a demonstration of the proposed principle.