Aggregation Dynamics of Blood Platelets

Platelet aggregation at sites of vascular injury is necessary for hemostasis and arterial thrombosis and occurs via platelet–platelet adhesion, tethering and rolling on the injured endothelium, a critical initial step in blood clot formation. In straight vessels, the presence of erythrocytes, red blood cells (RBCs) is known to push platelets toward walls, which may affect platelet aggregation and thrombus formation.
Blood Cells for required optimizing coagulation. Model predictions on platelet to platelet collisions and of platelets to the capillary wall showed that platelet size, platelet Young’s modulus and shear rate are most significant variables controlling capillary aggregation and thrombus. Results are compared with available experimental results.