Physics of the Brain. Prevention of the Epileptic Seizures by the Multi-photon Pulsed-operated Fiber Lasers in the Ultraviolet Range of Frequencies.

The novel study of the epileptogenesis mechanisms\footnote{ E.M. Goldberg and D.A Coulter, Nat. Rev. Neurosci.14(5), 337 (2013).} is proposed. It is based on the pulsed-operated (amplitude modulation) multi-photon (frequency modulation) fiber-laser interaction with the brain epilepsy-topion (the epilepsy onset area),\footnote{ V. Stefan, B. I. Cohen, C. Joshi, \textit{Science}, 243, 4890, (1989); Stefan et al., Bull. APS 32, No.9, 1713, (1987); Stefan, APS-March-2015, {\#} P1.00099;\textbf{~}Stefan, APS-March-2016, {\#}M1.00310;\textbf{~}V. Alexander Stefan, Neurophysics\textit{, Stem Cell Physics, and Genomic Physics: Beat-Wave-Driven-Free Electron Laser Beam Interactions with the Living Matter}, (S-U-Press, La Jolla, CA, 2012).\par } so as to prevent the excessive electrical discharge (epileptic seizure) in the brain. The repetition frequency, $\Omega $, matches the low frequency (epileptic) phonon waves in the brain. The laser repetition frequency (5-100 pulses per second) enables the resonance-scanning of the wide range of the phonon (possible epileptic-to-be) activity in the brain. The tunable fiber laser frequencies, $\Delta \omega $ (multi photon operation), are in the ultraviolet frequency range, thus enabling monitoring of the electrical charge imbalance (within the 10s of milliseconds), and the DNA-corruption in the epilepsy-topion, as the possible cause of the disease.