Active matter model of Myxococcus xanthus aggregation

ORAL

Abstract

\emph{Myxococcus xanthus} is a soil-dwelling bacterium that exhibits several fascinating collective behaviors including streaming, swarming, and generation of fruiting bodies. A striking feature of \emph{M. xanthus} is that it periodically reverses its motility direction. The first stage of fruiting body formation is characterized by the aggregation of cells on a surface into round mesoscopic structures. Experiments have shown that this aggregation relies heavily on regulation of the reversal rate and local mechanical interactions, suggesting motility-induced phase separation may play an important role. We have adapted self-propelled particle models to include cell reversal and motility suppression resulting from sporulation observed in aggregates. Using 2D molecular dynamics simulations, we map the phase behavior in the space of P\'eclet number and local density and examine the kinetics of aggregation for comparison to experiments.

Authors

  • Adam Patch

    Department of Physics, Syracuse University, Syracuse University

  • Fatmagul Bahar

    Department of Biology, Syracuse University, Syracuse University

  • Guannan Liu

    Department of Physics, Princeton University, Princeton University

  • Shashi Thutupalli

    Department of Physics, Princeton University; Lewis-Sigler Institute for Integrative Genomics, Princeton University

  • Roy Welch

    Department of Biology, Syracuse University, Syracuse University

  • David Yllanes

    Department of Physics, Syracuse University, Syracuse University

  • Joshua Shaevitz

    Princeton University, Department of Physics, Princeton University; Lewis-Sigler Institute for Integrative Genomics, Princeton University

  • M. Cristina Marchetti

    Syracuse Univ, Department of Physics, Syracuse University; Syracuse Biomaterials Institute, Syracuse University, Syracuse University, Department of Physics, Syracuse University