\textbf{Selective plasmon enhancement of fluorescence towards point of care disease diagnostics}

ORAL

Abstract

Surface plasmon coupled emission (SPCE) is a novel analytical technique in which the isotropic emission of a fluorophore is combined with the surface plasmon resonance of a metal thin film to yield highly directional emission from the so-called plasmaphore and thus greatly increased sensitivity. The optimal SPCE enhancement is achieved by introducing a spacer layer to mitigate fluorescence-quenching arising from metal-fluorophore interactions. ~Here we report a \textgreater 10-fold amplification of rhodamine B (RhB) fluorophore when carbon nanomaterials are used as the spacer layer. By combining experimental and density functional theory studies, we found that the rehybridization between CNMs and RhB results in emission redshift. We present SPCE-based biosensors for smart-phone based sensing of different analytes including biomarkers for diseases such as tuberculosis.

Authors

  • Bishwambhar Sengupta

    Clemson University

  • Jingyi Zhu

    Clemson University

  • Ramakrishna Podila

    Clemson Univeristy

  • Apparao Rao

    Clemson Univeristy, Clemson Nanomaterials Center, Laboratory of Nano-biophysics and COMSET, Dept. of Physics and Astronomy, Clemson University, Clemson, SC USA 29634, Clemson Nanomaterials Center, Dept., of Physics and Astronomy, Clemson University, Clemson, Laboratory of Nano-biophysics and COMSET