Cancer Progression and Tumor Growth Kinetics

ORAL

Abstract

We present and analyze tumor growth data from prostate and brain cancer. Scaling the data from different patients shows that early stage prostate tumors show non-exponential growth while advanced prostate and brain tumors enter a stage of exponential growth. The scaling analysis points to the existence of cancer stem cells and/or massive apoptosis in early stage prostate cancer and that late stage cancer growth is not dominated by cancer stem cells. Statistical models of these two growth modes are discussed.

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Authors

  • Krastan Blagoev

    Physics Division, National Science Foundation, Arlington, VA 22180, USA

  • Jayashree Kalpathy-Cramer

    Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Stre

  • Julia Wilkerson

    National Cancer Institute, National Institutes of Health, Building 10, 10 Center Drive, Bethesda, MD 20892, USA

  • Sara Sprinkhuizen

    Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Stre

  • Yi-Qiao Song

    Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Stre

  • Susan Bates

    Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Stre

  • Bruce Rosen

    Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Stre

  • Tito Fojo

    National Cancer Institute, National Institutes of Health, Building 10, 10 Center Drive, Bethesda, MD 20892, USA