Cell motility: Combining experiments with modeling

Cell migration and motility is a pervasive process in many biology systems. It involves intra-cellular signal transduction pathways that eventually lead to membrane extension and contraction. Here we describe our efforts to combine quantitative experiments with theoretical and computational modeling to gain fundamental insights into eukaryotic cell motion. In particular, we will focus on the amoeboid motion of Dictyostelium discoideum cells.