Rapid Antibiotic Resistance Evolution of GASP Mutants

ORAL

Abstract

The GASP phenotype in bacteria is due to a mutation which enables the bacteria to grow under high stress conditions where other bacteria stop growing. We probe using our Death Galaxy microenvironment how rapidly the GASP mutant can evolve resistance to mutagenic antibiotics compared to wild-type bacteria, and explore the genomic landscape changes due to the evolution of resistance.

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Authors

  • Qiucen Zhang

    Princeton University

  • Hyunsung Kim

    UC Santa Cruz

  • Nader Pourmand

    UC Santa Cruz

  • Robert Austin

    Physics, Princeton University, Princeton University, Department of Physics, Princeton University, Princeton NJ 08544, Department of Physics, Princeton University