The Statistics of DNA Capture and Re-Capture by Solid-State Nanopores

We studied repeated electrophoretic translocations of the same DNA molecule through $\sim $10 nm nanopores using the voltage-reversal re-capture technique. Correlations were observed in the folding conformations of molecules re-captured within the Zimm relaxation time of the polymer. A trend was observed, whereby more compact conformations of DNA evolved over time. Consecutive event charge deficit measurements were narrowly distributed about a well defined mean, suggesting that the analysis of multiple translocations through a pore can be used to improve estimates of the length of long polymers.